Japan Health Research Promotion Bureau

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Epidemiological study on Covid-19 among the staff of national centers


Heath care workers, especially those who are working in the care of patients with coronavirus disease 2019 (Covid-19), are at high risk of SARS-CoV-2 infection. We designed repeat serological surveys among the staff of six national centers during the epidemic of Covid-19. In each survey, we measure antibodies against SARS-CoV-2 nucleocapsid and spike proteins to assess cumulative infection and immunogenicity due to natural infection or vaccination. We also assess Covid-19-related stress and the depressive state of staff.

Epidemiological study on Covid-19 among the staff of National Research Centers for Advanced and Specialized Medical Care


  • To assess the spread of SARS-CoV-2 infection among health care workers
  • To identify preventive and risk factors of SARS-CoV-2 infection
  • To examine mental health status in relation to occupational and non-occupational factors
  • To evaluate antibody titers and risk of Covid-19 after vaccination

Comments from principal researcher

We will clarify the spread of infection and immunogenicity, as well as mental and physical health among health care workers, through continual serological surveys among staff of national centers during the Covid-19 epidemic. This study is expected to provide epidemiologic data for the protection of health care workers against SARS-CoV-2 infection and the management of their own health during the long-lasting epidemic. It will also inform health professionals and policy makers on future national health challenges.