Establishment of research infrastructure for single-cell spatial pathogenomics

Abstract

Recent progress in spatial transcriptomics is starting to provide invaluable information in spatial organization of not only normal tissues but also those affected by a variety of diseases. Our project aims to exploit advances in spatial transcriptomics in combination with single-cell analyses and highly-multiplexed immunofluorescence studies, and integrate these studies. This will lead to better understanding of molecular pathology of a variety of diseases, and development of innovative diagnostics and therapeutics.

Perspectives

• Deeper understanding of disease pathology
• Identification of novel diagnostic markers
• Development of collaborative research platforms among national centers

Comments from principal researcher

Through these integrative studies, we aim to build a powerful platform to understand dysregulated cellular networks in a variety of diseases.