Establishment of research infrastructure for single-cell spatial pathogenomics
Recent progress in spatial transcriptomics is starting to provide invaluable information in spatial organization of not only normal tissues but also those affected by a variety of diseases. Our project aims to exploit advances in spatial transcriptomics in combination with single-cell analyses and highly-multiplexed immunofluorescence studies, and integrate these studies. This will lead to better understanding of molecular pathology of a variety of diseases, and development of innovative diagnostics and therapeutics.
- Deeper understanding of disease pathology
- Identification of novel diagnostic markers
- Development of collaborative research platforms among national centers
Comments from principal researcher
Through these integrative studies, we aim to build a powerful platform to understand dysregulated cellular networks in a variety of diseases.